Ausgewählte aktuelle Publikationen

Hasegawa D, Sato R, Prasitlumkum N, Nishida K. Effect of Premorbid Beta-Blockers on Mortality in Patients With Sepsis: A Systematic Review and Meta-Analysis. J Intensive Care Med. 2021 Nov 23:8850666211052926. doi: 10.1177/08850666211052926. Epub ahead of print. PMID: 34812680.

Bellan M, Baricich A, Patrucco F, Zeppegno P, Gramaglia C, Balbo PE, Carriero A, Amico CS, Avanzi GC, Barini M, Battaglia M, Bor S, Cantaluppi V, Cappellano G, Ceruti F, Chiocchetti A, Clivati E, Giordano M, Cuneo D, Gambaro E, Gattoni E, Loro A, Manfredi M, Morosini U, Murano F, Paracchini E, Patti G, Pinato DJ, Raineri D, Rolla R, Sainaghi PP, Tricca S, Pirisi M. Long-term sequelae are highly prevalent one year after hospitalization for severe COVID-19. Sci Rep. 2021 Nov 22;11(1):22666. doi: 10.1038/s41598-021-01215-4

Deng JZ, Chan JS, Potter AL, Chen YW, Sandhu HS, Panda N, Chang DC, Yang CJ. The Risk of Postoperative Complications following Major Elective Surgery in Active or Resolved COVID-19 in the United States. Ann Surg. 2021 Nov 18. doi: 10.1097/SLA.0000000000005308. Epub ahead of print.

Holmbom M, Andersson M, Berg S, Eklund D, Sobczynski P, Wilhelms D, Moberg A, Fredrikson M, Balkhed ÅÖ, Hanberger H. Prehospital delay is an important risk factor for mortality in community-acquired bloodstream infection (CA-BSI): a matched case-control study. BMJ Open. 2021 Nov 18;11(11):e052582. doi: 10.1136/bmjopen-2021-052582. PMID: 34794994.

Tsou PY, Yo CH, Hsein YC, Yungtum G, Hsu WT, Chung JY, Su KY, Chang A, Chang IJ, Lee CC; National Taiwan University Hospital, Health Data Science Research Group. Temporal Trends in the Microbiological Characteristics of Sepsis in the United States: A Population Based Study. J Intensive Care Med. 2021 Nov 17:8850666211053778. doi: 10.1177/08850666211053778. Epub ahead of print.

Fleischmann-Struzek C, Rose N, Reinhart K. Sepsisassoziierte Todesfälle in Deutschland: Charakteristika und regionale Variation [Sepsis-associated deaths in Germany: characteristics and regional variation]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2021 Nov 8:1–8. German. doi: 10.1007/s00103-021-03427-5. Epub ahead of print.

Hayes LD, Ingram J, Sculthorpe NF. More Than 100 Persistent Symptoms of SARS-CoV-2 (Long COVID): A Scoping Review. Front Med (Lausanne). 2021 Nov 1;8:750378. doi: 10.3389/fmed.2021.750378.

Fleischmann-Struzek C, Rose N, Freytag A, Spoden M, Prescott HC, Schettler A, Wedekind L, Ditscheid B, Storch J, Born S, Schlattmann P, Günster C, Reinhart K, Hartog CS. Epidemiology and Costs of Postsepsis Morbidity, Nursing Care Dependency, and Mortality in Germany, 2013 to 2017. JAMA Netw Open. 2021 Nov 1;4(11):e2134290. doi: 10.1001/jamanetworkopen.2021.34290.

Simon EL, Truss K, Smalley CM, Mo K, Mangira C, Krizo J, Fertel BS. Improved hospital mortality rates after the implementation of emergency department sepsis teams. Am J Emerg Med. 2021 Oct 25;51:218-222. doi: 10.1016/j.ajem.2021.10.035.

Lee CC, Ho CY, Chen PL, Hsieh CC, Wang WYC, Lin CH, Ko WC. Is qSOFA Suitable for Early Diagnosis of Sepsis Among Bacteremia Patients in Emergency Departments? Time for a Reappraisal of Sepsis-3 Criteria. Front Med (Lausanne). 2021 Oct 20;8:743822. doi: 10.3389/fmed.2021.743822.

Evans L, Rhodes A, Alhazzani W, Antonelli M, Coopersmith CM, French C, Machado FR, Mcintyre L, Ostermann M, Prescott HC, Schorr C, Simpson S, Wiersinga WJ, Alshamsi F, Angus DC, Arabi Y, Azevedo L, Beale R, Beilman G, Belley-Cote E, Burry L, Cecconi M, Centofanti J, Coz Yataco A, De Waele J, Dellinger RP, Doi K, Du B, Estenssoro E, Ferrer R, Gomersall C, Hodgson C, Møller MH, Iwashyna T, Jacob S, Kleinpell R, Klompas M, Koh Y, Kumar A, Kwizera A, Lobo S, Masur H, McGloughlin S, Mehta S, Mehta Y, Mer M, Nunnally M, Oczkowski S, Osborn T, Papathanassoglou E, Perner A, Puskarich M, Roberts J, Schweickert W, Seckel M, Sevransky J, Sprung CL, Welte T, Zimmerman J, Levy M. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med. 2021 Oct 2:1–67. doi: 10.1007/s00134-021-06506-y. Epub ahead of print.

Definition, Grundlagen und Pathophysiologie, Leitlinien

Definition der Sepsis

Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, Hotchkiss RS, Levy MM, Marshall JC, Martin GS, Opal SM, Rubenfeld GD, van der Poll T, Vincent JL, Angus DC. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016 Feb 23;315(8):801-10. doi: 10.1001/jama.2016.0287

Grundlagen und Pathophysiologie

Hotchkiss RS, Moldawer LL, Opal SM, Reinhart K, Turnbull IR, Vincent JL. Sepsis and septic shock. Nat Rev Dis Primers. 2016 Jun 30;2:16045. doi: 10.1038/nrdp.2016.45

Angus DC, van der Poll T. Severe sepsis and septic shock. N Engl J Med. 2013 Aug 29;369(9):840-51. doi: 10.1056/NEJMra1208623 Erratum in: N Engl J Med. 2013 Nov 21;369(21):2069

Leitlinien

Brunkhorst FM, Weigand MA, Pletz M, Gastmeier P, Lemmen SW, Meier-Hellmann A, Ragaller M, Weyland A, Marx G, Bucher M, Gerlach H, Salzberger B, Grabein B, Welte T, Werdan K, Kluge S, Bone HG, Putensen C, Rossaint R, Quintel M, Spies C, Weiß B, John S, Oppert M, Jörres A, Brenner T, Elke G, Gründling M, Mayer K, Weimann A, Felbinger TW, Axer H; Deutsche Sepsis Gesellschaft e. V.. S3-Leitlinie Sepsis – Prävention, Diagnose, Therapie und Nachsorge : Langfassung [S3 Guideline Sepsis-prevention, diagnosis, therapy, and aftercare : Long version. Med Klin Intensivmed Notfmed. 2020 May;115(Suppl 2):37-109. German. doi: 10.1007/s00063-020-00685-0.

Eine kritische Stellungnahme zur S3-Leitlinie ist HIER veröffentlicht

Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, Kumar A, Sevransky JE, Sprung CL, Nunnally ME, Rochwerg B, Rubenfeld GD, Angus DC, Annane D, Beale RJ, Bellinghan GJ, Bernard GR, Chiche JD, Coopersmith C, De Backer DP, French CJ, Fujishima S, Gerlach H, Hidalgo JL, Hollenberg SM, Jones AE, Karnad DR, Kleinpell RM, Koh Y, Lisboa TC, Machado FR, Marini JJ, Marshall JC, Mazuski JE, McIntyre LA, McLean AS, Mehta S, Moreno RP, Myburgh J, Navalesi P, Nishida O, Osborn TM, Perner A, Plunkett CM, Ranieri M, Schorr CA, Seckel MA, Seymour CW, Shieh L, Shukri KA, Simpson SQ, Singer M, Thompson BT, Townsend SR, Van der Poll T, Vincent JL, Wiersinga WJ, Zimmerman JL, Dellinger RP. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Intensive Care Med. 2017 Mar;43(3):304-377. doi: 10.1007/s00134-017-4683-6

Epidemiologie, Krankheitslast und Krankheitskosten

Tzu-Han L, Lin CL, Lin CH, Wu MC, Wei JC. Children With Appendectomy Have Increased Risk of Future Sepsis: Real-world Data in Taiwan. Int J Clin Pract. 2021 Sep 22:e14912. doi: 10.1111/ijcp.14912. Epub ahead of print.

Rose N, Matthäus-Krämer C, Schwarzkopf D, Scherag A, Born S, Reinhart K, Fleischmann-Struzek C. Association between sepsis incidence and regional socioeconomic deprivation and health care capacity in Germany - an ecological study. BMC Public Health. 2021 Sep 7;21(1):1636. doi: 10.1186/s12889-021-11629-4

Bruno RR, Wernly B, Mamandipoor B, Rezar R, Binnebössel S, Baldia PH, Wolff G, Kelm M, Guidet B, De Lange DW, Dankl D, Koköfer A, Danninger T, Szczeklik W, Sigal S, van Heerden PV, Beil M, Fjølner J, Leaver S, Flaatten H, Osmani V, Jung C. ICU-Mortality in Old and Very Old Patients Suffering From Sepsis and Septic Shock. Front Med (Lausanne). 2021 Jul 9;8:697884. doi: 10.3389/fmed.2021.697884

Markwart R, Saito H, Harder T, Tomczyk S, Cassini A, Fleischmann-Struzek C, Reichert F, Eckmanns T, Allegranzi B. Epidemiology and burden of sepsis acquired in hospitals and intensive care units: a systematic review and meta-analysis. Intensive Care Med. 2020 Aug;46(8):1536-1551. doi: 10.1007/s00134-020-06106-2

Fleischmann-Struzek C, Mellhammar L, Rose N, Cassini A, Rudd KE, Schlattmann P, Allegranzi B, Reinhart K. Incidence and mortality of hospital- and ICU-treated sepsis: results from an updated and expanded systematic review and meta-analysis. Intensive Care Med. 2020 Aug;46(8):1552-1562. doi: 10.1007/s00134-020-06151-x

Buchman TG, Simpson SQ, Sciarretta KL, Finne KP, Sowers N, Collier M, Chavan S, Oke I, Pennini ME, Santhosh A, Wax M, Woodbury R, Chu S, Merkeley TG, Disbrow GL, Bright RA, MaCurdy TE, Kelman JA. Sepsis Among Medicare Beneficiaries: 1. The Burdens of Sepsis, 2012-2018. Crit Care Med. 2020 Mar;48(3):276-288. doi: 10.1097/CCM.0000000000004224

Rudd KE, Johnson SC, Agesa KM, Shackelford KA, Tsoi D, Kievlan DR, Colombara DV, Ikuta KS, Kissoon N, Finfer S, Fleischmann-Struzek C, Machado FR, Reinhart KK, Rowan K, Seymour CW, Watson RS, West TE, Marinho F, Hay SI, Lozano R, Lopez AD, Angus DC, Murray CJL, Naghavi M. Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study. Lancet. 2020 Jan 18;395(10219):200-211. doi: 10.1016/S0140-6736(19)32989-7

Fleischmann-Struzek C, Mikolajetz A, Schwarzkopf D, Cohen J, Hartog CS, Pletz M, Gastmeier P, Reinhart K. Challenges in assessing the burden of sepsis and understanding the inequalities of sepsis outcomes between National Health Systems: secular trends in sepsis and infection incidence and mortality in Germany. Intensive Care Med. 2018 Nov;44(11):1826-1835. doi: 10.1007/s00134-018-5377-4

Fleischmann-Struzek C, Thomas-Rüddel DO, Schettler A, Schwarzkopf D, Stacke A, Seymour CW, Haas C, Dennler U, Reinhart K. Comparing the validity of different ICD coding abstraction strategies for sepsis case identification in German claims data. PLoS One. 2018 Jul 30;13(7):e0198847. doi: 10.1371/journal.pone.0198847

Fleischmann-Struzek C, Goldfarb DM, Schlattmann P, Schlapbach LJ, Reinhart K, Kissoon N. The global burden of paediatric and neonatal sepsis: a systematic review. Lancet Respir Med. 2018 Mar;6(3):223-230. doi: 10.1016/S2213-2600(18)30063-8

SepNet Critical Care Trials Group. Incidence of severe sepsis and septic shock in German intensive care units: the prospective, multicentre INSEP study. Intensive Care Med. 2016 Dec;42(12):1980-1989. doi: 10.1007/s00134-016-4504-3

Rhee C, Dantes R, Epstein L, Murphy DJ, Seymour CW, Iwashyna TJ, Kadri SS, Angus DC, Danner RL, Fiore AE, Jernigan JA, Martin GS, Septimus E, Warren DK, Karcz A, Chan C, Menchaca JT, Wang R, Gruber S, Klompas M; CDC Prevention Epicenter Program. Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014. JAMA. 2017 Oct 3;318(13):1241-1249. doi: 10.1001/jama.2017.13836

Mellhammar L, Wullt S, Lindberg Å, Lanbeck P, Christensson B, Linder A. Sepsis Incidence: A Population-Based Study. Open Forum Infect Dis. 2016 Dec 8;3(4):ofw207. doi: 10.1093/ofid/ofw207

Kaukonen KM, Bailey M, Suzuki S, Pilcher D, Bellomo R. Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012. JAMA. 2014 Apr 2;311(13):1308-16. doi: 10.1001/jama.2014.2637

Prävention und Impfungen

Christiansen CF, Thomsen RW, Schmidt M, Pedersen L, Sørensen HT. Influenza vaccination and 1-year risk of myocardial infarction, stroke, heart failure, pneumonia, and mortality among intensive care unit survivors aged 65 years or older: a nationwide population-based cohort study. Intensive Care Med. 2019 Jul;45(7):957-967. doi: 10.1007/s00134-019-05648-4

Bonten MJ, Huijts SM, Bolkenbaas M, Webber C, Patterson S, Gault S, van Werkhoven CH, van Deursen AM, Sanders EA, Verheij TJ, Patton M, McDonough A, Moradoghli-Haftvani A, Smith H, Mellelieu T, Pride MW, Crowther G, Schmoele-Thoma B, Scott DA, Jansen KU, Lobatto R, Oosterman B, Visser N, Caspers E, Smorenburg A, Emini EA, Gruber WC, Grobbee DE. Polysaccharide conjugate vaccine against pneumococcal pneumonia in adults. N Engl J Med. 2015 Mar 19;372(12):1114-25. doi: 10.1056/NEJMoa1408544

Gastmeier P, Brunkhorst F, Schrappe M, Kern W, Geffers C. Wie viele nosokomiale Infektionen sind vermeidbar? [How many nosocomial infections are avoidable?]. Dtsch Med Wochenschr. 2010 May;135(3):91-3. German. doi: 10.1055/s-0029-1244823

Folgen von Sepsis und Covid-19

Crook H, Raza S, Nowell J, Young M, Edison P. Long covid-mechanisms, risk factors, and management. BMJ. 2021 Jul 26;374:n1648. doi: 10.1136/bmj.n1648. Erratum in: BMJ. 2021 Aug 3;374:n1944

Fernández-de-Las-Peñas C, Palacios-Ceña D, Gómez-Mayordomo V, Florencio LL, Cuadrado ML, Plaza-Manzano G, Navarro-Santana M. Prevalence of post-COVID-19 symptoms in hospitalized and non-hospitalized COVID-19 survivors: A systematic review and meta-analysis. Eur J Intern Med. 2021 Jun 16:S0953-6205(21)00208-9. doi: 10.1016/j.ejim.2021.06.009

Fleischmann-Struzek C, Kesselmeier M, Ouart D, Hartog CS, Bauer M, Bercker S, Bucher M, Meier-Hellmann A, Petros S, Schreiber T, Simon P, Weidhase L, Born S, Braune A, Chkirni H, Eichhorn C, Fiedler S, Gampe C, König C, Platzer S, Romeike H, Töpfer K, Reinhart K, Scherag A. Mid-German Sepsis Cohort (MSC): a prospective observational study of sepsis survivorship. BMJ Open. 2021 Mar 17;11(3):e043352. doi: 10.1136/bmjopen-2020-043352

Fleischmann-Struzek C, Rose N, Freytag A, Spoden M, Prescott HC,  Schettler A, Wedekind L, Ditscheid B, Storch J, Born S, Schlattmann P, Günster C, Reinhart K, Hartog CS. Epidemiology and costs of post-sepsis morbidity, nursing care dependency, and mortality in Germany medRxiv 2021.02.25.21252347. doi: 10.1101/2021.02.25.21252347

Schmidt K, Gensichen J, Fleischmann-Struzek C, Bahr V, Pausch C, Sakr Y, Reinhart K, Vollmar HC, Thiel P, Scherag A, Gantner J, Brunkhorst FM. Long-Term Survival Following Sepsis. Dtsch Arztebl Int. 2020 Nov 13;117(46):775-782. doi: 10.3238/arztebl.2020.0775

Hartog CS, Bodechtel U, Fleischmann-Struzek C, Denke C, Weiss B, Reinhart K. Sepsis: Die Folgen für betroffene Patienten und das Gesundheitssystem [Sepsis: Sequelae for Affected Patients and The Health Care System]. Dtsch Med Wochenschr. 2020 Feb;145(4):252-259. German. doi: 10.1055/a-1019-6379

Prescott HC, Iwashyna TJ, Blackwood B, Calandra T, Chlan LL, Choong K, Connolly B, Dark P, Ferrucci L, Finfer S, Girard TD, Hodgson C, Hopkins RO, Hough CL, Jackson JC, Machado FR, Marshall JC, Misak C, Needham DM, Panigrahi P, Reinhart K, Yende S, Zafonte R, Rowan KM, Angus DC. Understanding and Enhancing Sepsis Survivorship. Priorities for Research and Practice. Am J Respir Crit Care Med. 2019 Oct 15;200(8):972-981. doi: 10.1164/rccm.201812-2383CP

Liebl ME, Elmer N, Schwedtke C, Schröder I, Reißhauer A. Fachübergreifende Frührehabilitation nach Sepsis – Eine retrospektive Analyse  [Interdisciplinary Acute Medical Rehabilitation after Sepsis - A Retrospective Analysis]. Rehabilitation (Stuttg). 2018 Dec;57(6):372-380. German. doi: 10.1055/s-0043-117547

König C, Matt B, Kortgen A, Turnbull AE, Hartog CS. What matters most to sepsis survivors: a qualitative analysis to identify specific health-related quality of life domains. Qual Life Res. 2019 Mar;28(3):637-647. doi: 10.1007/s11136-018-2028-8

Prescott HC, Angus DC. Postsepsis Morbidity. JAMA. 2018 Jan 2;319(1):91. doi: 10.1001/jama.2017.19809

Yende S, Austin S, Rhodes A, Finfer S, Opal S, Thompson T, Bozza FA, LaRosa SP, Ranieri VM, Angus DC. Long-Term Quality of Life Among Survivors of Severe Sepsis: Analyses of Two International Trials. Crit Care Med. 2016 Aug;44(8):1461-7. doi: 10.1097/CCM.0000000000001658

Wintermann GB, Brunkhorst FM, Petrowski K, Strauss B, Oehmichen F, Pohl M, Rosendahl J. Stress disorders following prolonged critical illness in survivors of severe sepsis. Crit Care Med. 2015 Jun;43(6):1213-22. doi: 10.1097/CCM.0000000000000936

Pandharipande PP, Girard TD, Jackson JC, Morandi A, Thompson JL, Pun BT, Brummel NE, Hughes CG, Vasilevskis EE, Shintani AK, Moons KG, Geevarghese SK, Canonico A, Hopkins RO, Bernard GR, Dittus RS, Ely EW; BRAIN-ICU Study Investigators. Long-term cognitive impairment after critical illness. N Engl J Med. 2013 Oct 3;369(14):1306-16. doi: 10.1056/NEJMoa1301372

Iwashyna TJ, Ely EW, Smith DM, Langa KM. Long-term cognitive impairment and functional disability among survivors of severe sepsis. JAMA. 2010 Oct 27;304(16):1787-94. doi: 10.1001/jama.2010.1553

Effektivität von Qualitätsverbesserungsmaßnahmen

Khowaja AR, Willms AJ, Krause C, Carriere S, Ridout B, Kennedy C, Young E, Mitton C, Kissoon N, Sweet DD. The Return on Investment of a Province-Wide Quality Improvement Initiative for Reducing In-Hospital Sepsis Rates and Mortality in British Columbia, Canada. Crit Care Med. 2021 Sep 29. doi: 10.1097/CCM.0000000000005353. Epub ahead of print.

Frühe Diagnostik und TherapieWayne MT, Seelye S, Molling D, Wang XQ, Donnelly JP, Hogan CK, Jones MM, Iwashyna TJ, Liu VX, Prescott HC. Temporal Trends and Hospital Variation in Time-to-Antibiotics Among Veterans Hospitalized With Sepsis. JAMA Netw Open. 2021 Sep 1;4(9):e2123950. doi: 10.1001/jamanetworkopen.2021.23950

Townsend SR, Phillips GS, Duseja R, Tefera L, Cruikshank D, Dickerson R, Nguyen HB, Schorr CA, Levy MM, Dellinger RP, Conway WA, Browner WS, Rivers EP. Effects of Compliance with the Early Management Bundle (SEP-1) on Mortality Changes among Medicare Beneficiaries with Sepsis: A Propensity Score Matched Cohort Study. Chest. 2021 Aug 5:S0012-3692(21)03623-0. doi: 10.1016/j.chest.2021.07.2167

Prasad PA, Fang MC, Abe-Jones Y, Calfee CS, Matthay MA, Kangelaris KN. Time to Recognition of Sepsis in the Emergency Department Using Electronic Health Record Data: A Comparative Analysis of Systemic Inflammatory Response Syndrome, Sequential Organ Failure Assessment, and Quick Sequential Organ Failure Assessment. Crit Care Med. 2020 Feb;48(2):200-209. doi: 10.1097/CCM.0000000000004132

Taylor SP, Chou SH, Sierra MF, Shuman TP, McWilliams AD, Taylor BT, Russo M, Evans SL, Rossman W, Murphy S, Cunningham K, Kowalkowski MA. Association between Adherence to Recommended Care and Outcomes for Adult Survivors of Sepsis. Ann Am Thorac Soc. 2020 Jan;17(1):89-97. doi: 10.1513/AnnalsATS.201907-514OC

Kahn JM, Davis BS, Yabes JG, Chang CH, Chong DH, Hershey TB, Martsolf GR, Angus DC. Association Between State-Mandated Protocolized Sepsis Care and In-hospital Mortality Among Adults With Sepsis. JAMA. 2019 Jul 16;322(3):240-250. doi: 10.1001/jama.2019.9021

Evans IVR, Phillips GS, Alpern ER, Angus DC, Friedrich ME, Kissoon N, Lemeshow S, Levy MM, Parker MM, Terry KM, Watson RS, Weiss SL, Zimmerman J, Seymour CW. Association Between the New York Sepsis Care Mandate and In-Hospital Mortality for Pediatric Sepsis. JAMA. 2018 Jul 24;320(4):358-367. doi: 10.1001/jama.2018.9071

Machado FR, Ferreira EM, Schippers P, de Paula IC, Saes LSV, de Oliveira FI Jr, Tuma P, Nogueira Filho W, Piza F, Guare S, Mangini C, Guth GZ, Azevedo LCP, Freitas FGR, do Amaral JLG, Mansur NS, Salomão R; SPDM against sepsis project. Implementation of sepsis bundles in public hospitals in Brazil: a prospective study with heterogeneous results. Crit Care. 2017 Oct 31;21(1):268. doi: 10.1186/s13054-017-1858-z

Bloos F, Rüddel H, Thomas-Rüddel D, Schwarzkopf D, Pausch C, Harbarth S, Schreiber T, Gründling M, Marshall J, Simon P, Levy MM, Weiss M, Weyland A, Gerlach H, Schürholz T, Engel C, Matthäus-Krämer C, Scheer C, Bach F, Riessen R, Poidinger B, Dey K, Weiler N, Meier-Hellmann A, Häberle HH, Wöbker G, Kaisers UX, Reinhart K; MEDUSA study group. Effect of a multifaceted educational intervention for anti-infectious measures on sepsis mortality: a cluster randomized trial. Intensive Care Med. 2017 Nov;43(11):1602-1612. doi: 10.1007/s00134-017-4782-4

Seymour CW, Gesten F, Prescott HC, Friedrich ME, Iwashyna TJ, Phillips GS, Lemeshow S, Osborn T, Terry KM, Levy MM. Time to Treatment and Mortality during Mandated Emergency Care for Sepsis. N Engl J Med. 2017 Jun 8;376(23):2235-2244. doi: 10.1056/NEJMoa1703058

Scheer CS, Fuchs C, Kuhn SO, Vollmer M, Rehberg S, Friesecke S, Abel P, Balau V, Bandt C, Meissner K, Hahnenkamp K, Gründling M. Quality Improvement Initiative for Severe Sepsis and Septic Shock Reduces 90-Day Mortality: A 7.5-Year Observational Study. Crit Care Med. 2017 Feb;45(2):241-252. doi: 10.1097/CCM.0000000000002069

Burrell AR, McLaws ML, Fullick M, Sullivan RB, Sindhusake D. SEPSIS KILLS: early intervention saves lives. Med J Aust. 2016 Feb 1;204(2):73. doi: 10.5694/mja15.00657

Damiani E, Donati A, Serafini G, Rinaldi L, Adrario E, Pelaia P, Busani S, Girardis M. Effect of performance improvement programs on compliance with sepsis bundles and mortality: a systematic review and meta-analysis of observational studies. PLoS One. 2015 May 6;10(5):e0125827. doi: 10.1371/journal.pone.0125827

Mouncey PR, Osborn TM, Power GS, Harrison DA, Sadique MZ, Grieve RD, Jahan R, Harvey SE, Bell D, Bion JF, Coats TJ, Singer M, Young JD, Rowan KM; ProMISe Trial Investigators. Trial of early, goal-directed resuscitation for septic shock. N Engl J Med. 2015 Apr 2;372(14):1301-11. doi: 10.1056/NEJMoa1500896

ARISE Investigators; ANZICS Clinical Trials Group, Peake SL, Delaney A, Bailey M, Bellomo R, Cameron PA, Cooper DJ, Higgins AM, Holdgate A, Howe BD, Webb SA, Williams P. Goal-directed resuscitation for patients with early septic shock. N Engl J Med. 2014 Oct 16;371(16):1496-506. doi: 10.1056/NEJMoa1404380

ProCESS Investigators, Yealy DM, Kellum JA, Huang DT, Barnato AE, Weissfeld LA, Pike F, Terndrup T, Wang HE, Hou PC, LoVecchio F, Filbin MR, Shapiro NI, Angus DC. A randomized trial of protocol-based care for early septic shock. N Engl J Med. 2014 May 1;370(18):1683-93. doi: 10.1056/NEJMoa1401602

Vermeidung und Behandlung von Folgen

Schmidt K, Worrack S, Von Korff M, Davydow D, Brunkhorst F, Ehlert U, Pausch C, Mehlhorn J, Schneider N, Scherag A, Freytag A, Reinhart K, Wensing M, Gensichen J; SMOOTH Study Group. Effect of a Primary Care Management Intervention on Mental Health-Related Quality of Life Among Survivors of Sepsis: A Randomized Clinical Trial. JAMA. 2016 Jun 28;315(24):2703-11. doi: 10.1001/jama.2016.7207

Prescott HC, Angus DC. Enhancing Recovery From Sepsis: A Review. JAMA. 2018 Jan 2;319(1):62-75. doi: 10.1001/jama.2017.17687

Gesundheitskompetenz, Sepsiswissen

Eitze S, Fleischmann-Struzek C, Betsch C, Reinhart K; vaccination60+ study group. Determinants of sepsis knowledge: a representative survey of the elderly population in Germany. Crit Care. 2018 Oct 28;22(1):273. doi: 10.1186/s13054-018-2208-5

Sepsis Stiftung: Sepsis Bewusstsein in Deutschland - Ergebnisse der Umfrage (2017)

Sepsis Alliance: Sepsis awareness research - Survey Results (2016)

Rubulotta FM, Ramsay G, Parker MM, Dellinger RP, Levy MM, Poeze M; Surviving Sepsis Campaign Steering Committee; European Society of Intensive Care Medicine; Society of Critical Care Medicine. An international survey: Public awareness and perception of sepsis. Crit Care Med. 2009 Jan;37(1):167-70. doi: 10.1097/ccm.0b013e3181926883

Untersuchungsberichte und Stellungnahmen zu Defiziten und Struktur des Gesundheitswesens mit Relevanz für die Versorgungsqualität

European Society of Intensive Care Medicine (ESICM); Global Sepsis Alliance (GSA); Society of Critical Care Medicine (SCCM). Reducing the global burden of sepsis: a positive legacy for the COVID-19 pandemic? Intensive Care Med. 2021 Jul;47(7):733-736. doi: 10.1007/s00134-021-06409-y

Gesundheitsbericht der Europäischen Union EU - Länderspezifische Gesundheitsprofile

Sepsis Stiftung: Nationaler Sepsisplan – Handlungsfelder und Maßnahmen - Memorandum 2017

Sepsis Stiftung: Nationaler Aktionsplan gegen Sepsis - Memorandum 2013

Sepsis Stiftung: Dossier - Vergleichende Analyse von Strukturmerkmalen der Gesundheitssysteme und politischen Reaktionsmuster auf die Herausforderungen durch Sepsis in Ländern mit unterschiedlicher Sepsissterblichkeit - Dossier 2018

WHO Sepsis Resolution WHA 70.7: Improving the prevention, diagnosis and clinical management of sepsis - Resolution 2017

Reinhart K, Daniels R, Kissoon N, Machado FR, Schachter RD, Finfer S. Recognizing Sepsis as a Global Health Priority - A WHO Resolution. N Engl J Med. 2017 Aug 3;377(5):414-417. doi: 10.1056/NEJMp1707170

WHO Report Epidemiology of Sepsis 2020 - Sepsis Report 2020

World Sepsis Declaration 2030 - Declaration

Clinical Excellence Commission Australia: Recognition and Management of Sepsis - Clinical Focus Report 2012

Irland: National Sepsis Report - Report 2019

New York State Report on Sepsis Care Improvement Initiative: Hospital Quality Performance - Report 2017

UK: National Confidential Enquiry into Patient Outcome and Death „Just say Sepsis“ - NCEPOD 2015

UK: Parliamentary and Health Service Ombudsman – Time to Act. Severe sepsis: rapid diagnosis and treatment saves lives - Clinical Report 2013

Wunsch H, Angus DC, Harrison DA, Collange O, Fowler R, Hoste EA, de Keizer NF, Kersten A, Linde-Zwirble WT, Sandiumenge A, Rowan KM. Variation in critical care services across North America and Western Europe. Crit Care Med. 2008 Oct;36(10):2787-93, e1-9. doi: 10.1097/CCM.0b013e318186aec8

Organisation for Economic Co-operation and Development: Doctors' consultations - OECD indicator

Organisation for Economic Co-operation and Development: Hospital beds - OECD indicator

Organisation for Economic Co-operation and Development: nurses - OECD indicator

Organisation for Economic Co-operation and Development: Health at a glance - OECD Report 2019